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Within the cyst(e)ine/GSH/GPX4 axis, cysteine is the rate-limiting metabolite for GSH biosynthesis, hence the ferroptosis-inducing activity of cyst(e)ine depletion has largely been attributed to the lowering of intracellular GSH levels and subsequent decrease of GPX4 activity

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In Epidemics, Hippocrates (460370 BCE) provided the first clear description of migraine with aura, linking it to vascular dilation and recording visual premonitory symptoms (scintillating scotomas) that precede headache attacks

Furthermore, the regulator of G protein signaling 2 is implicated in the modulation of GPCR signaling, particularly the reduction of Gq-coupled receptor activity, which is associated with bronchoconstriction and inflammation in asthma [173]